Clinical Research Capabilities
Experience, Infrastructure, and Patient Access Across One Integrated Network
M3 Wake Research supports Phase I through Phase IV drug, device, vaccine, and observational studies across a broad range of therapeutic areas.
Our network brings together experienced investigators, specialized clinical capabilities, direct patient access, and centralized recruitment to support studies from feasibility through enrollment and completion.
Clinical Research Experience at a Glance
40+ Years of Clinical Research Experience
- 16+ Wholly Owned Sites Across 9 States
- 70+ Investigators
- 15+ Therapeutic Areas
- 670+ Studies Completed
- 1M+ Patient Database
- 30,000+ Participants Randomized
- 30+ Direct-Access Partnerships Nationwide
Therapeutic Experience
Supporting Complex and High-Demand Research Programs
M3 Wake Research supports clinical development programs across diverse therapeutic areas, patient populations, study phases, and protocol requirements.
- Cardiovascular disease
- Dermatology
- Endocrinology and metabolic disorders
- Gastroenterology and hepatology
- Infectious disease and vaccines
- Men’s health
- Neurology
- Obesity and weight management
- Pain management
- Psychiatry and behavioral health
- Pulmonology and respiratory conditions
- Women’s health
Our business development team evaluates each study opportunity against investigator experience, patient access, site infrastructure, and protocol requirements to identify the most appropriate research locations.
Network Experience Across Key Therapeutic Areas
Our network combines experienced investigators, established patient access, specialized clinical capabilities, and demonstrated performance across complex and competitive indications.
Endocrinology and Metabolic Research
- 3,800+ participants enrolled over the last five years
- 56 endocrinology trials
- 49 obesity trials
- 12 investigators with obesity and Type 2 diabetes trial experience
Neurology
- 395 studies conducted
- 3,242 participants randomized
- 91% reported study retention
- Five sites with neurologists
Psychiatry and Behavioral Health
- 89 studies conducted
- 580 participants randomized
- 82% reported study retention
- Six sites with psychiatric capabilities
Vaccines and Infectious Disease
- 260+ vaccine trials
- 21,000+ participants randomized
- 120% of enrollment goals reached across the reported portfolio
- 10 sites with vaccine experience
Women’s Health
- 7,497 participants screened
- 4,162 participants randomized
- 78% reported study retention
- Four sites with OB/GYN investigators
Endocrinology and Metabolic Research
Experience Across Interconnected Metabolic Conditions
M3 Wake Research supports studies involving Type 1 and Type 2 diabetes, obesity, thyroid disorders, cardiovascular risk, NASH/MASH, and related metabolic conditions.
Our network includes board-certified endocrinologists, obesity medicine specialists, and investigators experienced in managing overlapping indications, comorbidities, and complex metabolic protocols.
Indication Experience
- Type 1 and Type 2 diabetes
- Obesity and weight management
- Thyroid disorders and Graves’ disease
- Cardiovascular risk
- NASH/MASH
- Dyslipidemia
- Overweight with related comorbidities
Select Capabilities
- FibroScan
- Glucose clamping
- Continuous glucose monitoring
- Point-of-care HbA1c
- Thyroid ultrasound
- DEXA and body-composition assessment
- Long pharmacokinetic visits
- Infusion capabilities
- MRI coordination and liver biopsy access
Neurology
Supporting Complex CNS Studies
Our neurology experience spans migraine, Alzheimer’s disease, dementia, Parkinson’s disease, epilepsy, multiple sclerosis, stroke, neuropathic pain, spasticity, and related neurological conditions.
The network includes neurologists, experienced clinical trial raters, and research teams prepared to support complex assessments and longitudinal CNS protocols.
Indication Experience
- Alzheimer’s disease
- Dementia
- Epilepsy
- Migraine
- Multiple sclerosis
- Neuropathic pain
- Diabetic peripheral neuropathy
- Parkinson’s disease
- Postoperative pain management
- Stroke
- Upper- and lower-limb spasticity
Select Capabilities
- Experienced CNS raters
- Neuropsychological assessments
- Neurological examinations
- Longitudinal neurological assessments
- Acute, episodic, menstrual, chronic, and preventive migraine studies
- Oral, intravenous, nasal, subcutaneous, and neurotoxin administration experience
Psychiatry and Behavioral Health
Specialized Experience Across Diverse Psychiatric Populations
M3 Wake Research supports psychiatric studies involving depression, anxiety, PTSD, ADHD, bipolar disorder, substance use, schizophrenia, sleep disorders, obsessive-compulsive disorder, and treatment-resistant populations.
Our psychiatric research teams include experienced investigators, certified clinical raters, and multidisciplinary staff supporting adult, adolescent, geriatric, and high-acuity populations.
Indication Experience
- Generalized anxiety disorder
- Social anxiety disorder
- ADHD
- Binge eating disorder
- Bipolar disorder
- Insomnia
- Major depressive disorder
- Obsessive-compulsive disorder
- Opioid use disorder
- Post-traumatic stress disorder
- Schizophrenia
- Smoking cessation
- Treatment-resistant depression
Select Capabilities
- Experienced psychiatric and CNS raters
- Neuropsychological and psychometric assessments
- Private dosing and observation rooms
- Infusion readiness
- Spravato administration
- Transcranial magnetic stimulation
- Neuromodulation capabilities
- DEA scheduled investigational product readiness
- Interventional psychiatry expertise at select locations
Vaccines and Infectious Diseases
High-Throughput Enrollment Supported by Experienced Research Teams
M3 Wake Research has supported vaccine development across a wide range of infectious diseases, patient populations, and study phases.
Our network offers experience with rapid enrollment, cold-chain requirements, longitudinal follow-up, booster studies, and recruitment among older adults and high-risk populations.
Vaccine and Infectious Disease Experience
- Influenza
- COVID-19
- RSV
- Pneumococcal disease
- HPV
- Meningitis
- C. difficile
- Cytomegalovirus
- Chikungunya
- Rotavirus
- Shingles
- Hepatitis
- Dengue
- Tdap
- Measles, mumps, rubella, and varicella
- HIV
- Other emerging and infectious disease indications
Select Capabilities
- Temperature-controlled and ultra-low-temperature storage
- Cold-chain management
- PBMC processing
- Immunogenicity sample handling
- On-site or partnered laboratory services
- Longitudinal follow-up
- Booster-study experience
- Flexible visit scheduling
- Digital and remote study support at select locations
Women’s Health
Clinical and Procedural Experience Across the Women’s Health Journey
M3 Wake Research supports women’s health studies across reproductive health, gynecologic conditions, sexual health, pregnancy-related conditions, and menopause.
The network includes experienced OB/GYN investigators and research teams with access to diverse patient populations and a broad range of diagnostic and procedural capabilities.
Indication Experience
- Anemia
- Bacterial vaginosis
- Contraception
- Dysmenorrhea
- Endometriosis
- Heavy menstrual bleeding
- Hormone replacement therapy
- HPV
- Hypoactive sexual desire
- Polycystic ovary syndrome
- Postmenopausal conditions
- Postpartum depression
- Premenstrual dysphoric disorder
- Sexual dysfunction
- Urinary tract infections
- Uterine fibroids
- Vaginal atrophy
- Vasomotor symptoms
- Vulvovaginal candidiasis
Select Capabilities
- Pelvic examinations
- STI and vaginal infection evaluation
- Breast examinations
- Pap smears
- Endometrial biopsy
- Transvaginal ultrasound
- Abdominal ultrasound
- Colposcopy
- Loop electrosurgical excision procedures
- IUD placement and removal
Additional Therapeutic Capabilities
Experience Beyond Our Featured Research Areas
Our network also supports clinical research across additional therapeutic areas and medically complex patient populations.
Cardiovascular Disease
Experience across cardiovascular risk, hypertension, dyslipidemia, and cardiometabolic conditions, including studies requiring participants with multiple comorbidities.
Dermatology
Experience supporting dermatologic and autoimmune skin-condition studies across diverse patient populations.
Gastroenterology and Hepatology
Experience across gastrointestinal and liver conditions, supported by FibroScan, imaging coordination, liver biopsy access, and established clinical relationships at select locations.
Men’s Health
Experience supporting studies involving hormone health, sexual health, prevention, and related internal medicine conditions.
Pulmonology and Respiratory
Experience supporting asthma, respiratory disease, vaccine, and infectious disease studies, with spirometry and respiratory diagnostic capabilities at select locations.
Proven Enrollment Performance
Performance Across Complex and Competitive Studies
M3 Wake Research combines centralized recruitment strategy, direct-access partnerships, embedded site support, and trusted community relationships to help studies meet enrollment goals.
Our recruitment teams monitor performance from initial outreach through screening and randomization, allowing strategies to be adjusted based on actual conversion and enrollment results.
Vaccine Enrollment at Scale
In a recent vaccine study, participating M3 Wake Research sites achieved:
- 715 randomizations within 2.5 weeks of greenlight
- 1,391 leads generated
- 734 participants screened
- 20 days from first site selection to final site activation
This performance was supported by centralized recruitment planning, extensive candidate outreach, embedded site teams, and coordinated activation across participating locations.
Obesity and Type 2 Diabetes Rescue Performance
M3 Wake Research supported a recent obesity and Type 2 diabetes study as a multisite rescue network.
Results included:
- 7 investigators and sites supporting recruitment
- 100% of participating sites meeting enrollment goals
- 3 sites exceeding projected enrollment
- 80% more enrollment than originally projected
- Recruitment completed within a six-week rescue period
- Final site activation achieved within 35 days
The network combined experienced metabolic investigators, direct patient access, community partnerships, and centralized recruitment to rapidly expand enrollment opportunities.
Patient Access and Recruitment Capabilities
Connecting Study Opportunities With Established Patient Relationships
M3 Wake Research supports enrollment through a combination of direct-access partnerships, established patient relationships, centralized recruitment, and local engagement.
Our patient access and recruitment capabilities include:
- A 1M+ network patient database
- 30+ direct-access partnerships across the United States
- Protocol-aligned patient population assessment
- Physician- and partner-supported patient identification
- Direct collaboration with clinical and community practices
- Centralized recruitment strategy
- Embedded Patient Enrollment Coordinators
- Digital, print, community, and referral-based outreach
- Study-specific landing pages and digital pre-screening
- Multilingual participant engagement
- Lead-to-randomization conversion monitoring
- Retention-focused participant communication
Our direct-access partnerships expand the populations available for feasibility and recruitment while connecting study opportunities with trusted clinical relationships.
Find the Right Site for Your Protocol
M3 Wake Research combines centralized coordination with the investigator expertise, patient access, and specialized capabilities of 16+ wholly owned research sites.
Our business development team can help identify locations aligned with your:
- Therapeutic area
- Protocol requirements
- Target patient population
- Geographic needs
- Investigator qualifications
- Diagnostic and procedural requirements
- Study-phase experience
Each clinic page provides additional information about the location’s investigators, research experience, patient access, equipment, procedures, and site-specific differentiators.
Let’s Evaluate Your Study
Connect with our business development team to discuss protocol requirements, therapeutic experience, patient availability, site selection, and specialized capabilities.
News & Updates
Understanding Graves’ Disease: An Autoimmune Thyroid Disorder
September 30, 2025
Now Enrolling: Obesity and Type 2 Diabetes Studies at M3 Wake Research…
September 22, 2025
Understanding Obesity: A Deep Dive into Its Causes, Consequences &…
September 19, 2025
Clinical Research in the Community: Why Partnering with Community Phys…
September 11, 2025
